Transdiagnostic neuroimaging markers of psychiatric risk: A narrative review

Several decades of neuroimaging research in psychiatry have shed light on structural and functional neural abnormalities associated with individual psychiatric disorders. However, there is increasing evidence for substantial overlap the patterns dysfunction seen across disorders, suggesting that risk illness may be shared diagnostic boundaries. Gaining insights existence mechanisms which transdiagnostically underlie psychopathology important order to tease apart unique common aspects different but also clinically, so as help identify individuals early who biologically vulnerable disorder general. In this narrative review, we first evaluate recent studies investigating correlates a general factor, thought reflect variance mental health symptoms therefore index vulnerability. We then link from existing meta-analytic categorical conclude by providing an integrative account vulnerability illness, whereby delayed or disrupted maturation large-scale networks (particularly default-mode, executive, sensorimotor networks), more generally between-network connectivity, results compromised ability integrate switch between internally externally focused tasks.